MCM4 in human hepatocellular carcinoma: a potent prognostic factor associated with cell proliferation

Hepatocellular carcinoma (HCC) remains a major public health problem. MCM4, constitutive member of the minichromosomal maintenance protein family, has been reported to play vital role in cancer malignancy behavior. However, function MCM4 HCC largely unknown. The present study explored specific HCC. data from datasets including TCGA and GTEx showed that was overexpressed significantly associated with poor prognosis. Immunohistochemistry results 102 patients suggested high-level expression correlated tumor size. Then series vivo vitro experiments were performed investigate cells. silencing suppressed cell proliferation sphere formation hepatoma Moreover, decreased growth tumors xenograft model. In conclusion, indicated potential prognostic predictor outcomes even therapeutic target for